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In a bowl, add warm water and yeast. Wait about 5 minutes to allow the yeast to "proof". Stir after the 5 minutes to make sure yeast is completely dissolved.
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In another bowl, add flour, onion powder, garlic powder, sugar, oregano and Parmesan cheese. Mix well, then add olive oil and mix again.
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Combine both bowls into one and start kneading the mixture to create a dough consistency. Add more flour if necessary. Keep kneading until the dough is no longer sticky and feels soft to the touch.
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Roll the dough into a ball form.In a bowl, coat with oil and place ball of dough into bowl, rolling it around for a light coat. Put bowl aside for 2 to 3 hours to allow dough to rise.
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Once dough has risen (should be about double it's size), place on a lightly floured surface and use rolling pin to roll into a round shape for your pizza.
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Evenly spread desired amount of sauce and top with cheese and pepperonis.
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Bake at 475 for 11-12 minutes. Pizza will be done with dough is golden and cheese on top is completely melted.